Lab-created sperm breeds healthy mice, raising hopes for end to male infertility

Scientists hail landmark achievement, but warn that artificial human sperm is a distant prospect fraught with concerns over safety, ethics and legality. A handful of healthy mice made from sperm cells created in the lab have been hailed as a milestone in research that could ultimately provide new treatments for male infertility. Scientists in China […]

Clarifying the mechanism for making blood cells

In 1917, Florence Sabin, the first female member of the US National Academy of Sciences, discovered hemangioblasts, the common precursor cells for blood cells and blood vessel endothelia. Her discovery faced a great deal of critical opinions, but by the end of the 20th century, those opinions were overcome, and the existence of hemangioblasts had […]

Broken UV light leads to key heart muscle cell discovery

For a team of Vanderbilt investigators trying to generate heart muscle cells from stem cells, a piece of broken equipment turned out to be a good thing. The faulty equipment pushed the researchers to try a different approach. They recently reported their new method — using a “Matrigel mattress” to rapidly generate cardiac cells suitable […]

First human in vitro model of rare neurodegenerative condition created

Researchers at University of California, San Diego School of Medicine and Rady Children’s Hospital-San Diego have created the first stem cell-derived in vitro cellular model of a rare, but devastating, neurodegenerative condition called Cockayne syndrome (CS). The findings are published in the current online issue of the journal Human Molecular Genetics. CS is characterized by […]

A cancer’s surprise origins caught in action

Researchers at Boston Children’s Hospital have, for the first time, visualized the origins of cancer from the first affected cell and watched its spread in a live animal. Their work, published in the January 29th issue of Science, could change the way scientists understand melanoma and other cancers and could lead to new, early treatments […]